INPP5E antibody (AA 510-630)

Catalog No. ABIN7267883

The Rabbit Polyclonal anti-INPP5E antibody has been validated for WB, IF. It is suitable to detect INPP5E in samples from Human.

Quick Overview for INPP5E antibody (AA 510-630) (ABIN7267883)

Target: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INPP5E antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-INPP5E Antibody

Binding Specificity: AA 510-630

Purpose: INPP5E Rabbit pAb

Sequence: LIREMRKGSI FKGFQEPDIH FLPSYKFDIG KDTYDSTSKQ RTPSYTDRVL YRSRHKGDIC PVSYSSCPGI KTSDHRPVYG LFRVKVRPGR DNIPLAAGKF DRELYLLGIK RRISKEIQRQ Q

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for INPP5E

Target: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Alternative Name: INPP5E

Background: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome, a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],CORS1,CPD4,JBTS1,MORMS,PPI5PIV,pharbin,INPP5E,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,INPP5E

Molecular Weight: 66kDa/70kDa

Gene ID: 56623

UniProt: Q9NRR6