LYAR antibody (AA 10-160)

Catalog No. ABIN7268311

This Rabbit Polyclonal antibody specifically detects LYAR in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for LYAR antibody (AA 10-160) (ABIN7268311)

Target: LYAR (Ly1 Antibody Reactive (LYAR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LYAR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-LYAR Antibody

Binding Specificity: AA 10-160

Purpose: LYAR Rabbit pAb

Sequence: GESVKKIQVE KHVSVCRNCE CLSCIDCGKD FWGDDYKNHV KCISEDQKYG GKGYEGKTHK GDIKQQAWIQ KISELIKRPN VSPKVRELLE QISAFDNVPR KKAKFQNWMK NSLKVHNESI LDQVWNIFSE ASNSEPVNKE QDQRPLHPVA N

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 10-160 of human LYAR (NP_060286.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LYAR

Target: LYAR (Ly1 Antibody Reactive (LYAR))

Alternative Name: LYAR

Target Type: Antibody

Background: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2 promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs, which in turn is essential for ESC self-renewal (By similarity.,LYAR,ZC2HC2,ZLYAR,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,LYAR

Molecular Weight: 43kDa

Gene ID: 55646

UniProt: Q9NX58