MSL1 antibody (AA 210-300)

Catalog No. ABIN7268383

This Rabbit Polyclonal antibody specifically detects MSL1 in WB. It exhibits reactivity toward Human.

Quick Overview for MSL1 antibody (AA 210-300) (ABIN7268383)

Target: MSL1 (Male-Specific Lethal 1 Homolog (MSL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MSL1 Antibody

Binding Specificity: AA 210-300

Purpose: MSL1 Rabbit pAb

Sequence: LAVPSWRDHS VEPLRDPNPS DLLENLDDSV FSKRHAKLEL DEKRRKRWDI QRIREQRILQ RLQLRMYKKK GIQESEPEVT SFFPEPDDVE S

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human MSL1 (NP_001012241).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MSL1

Target: MSL1 (Male-Specific Lethal 1 Homolog (MSL1))

Alternative Name: MSL1

Background: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub. This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me and 'Lys-79' (H3K79me and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.,MSL-1,hMSL1,MSL1,Epigenetics & Nuclear Signaling,Histones,MSL1

Gene ID: 339287

UniProt: Q68DK7