MSL1 antibody (AA 210-300)
MSL1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target See all MSL1 Antibodies
- MSL1 (Male-Specific Lethal 1 Homolog (MSL1))
- Binding Specificity
- AA 210-300
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Purpose
- MSL1 Rabbit pAb
- Sequence
- LAVPSWRDHS VEPLRDPNPS DLLENLDDSV FSKRHAKLEL DEKRRKRWDI QRIREQRILQ RLQLRMYKKK GIQESEPEVT SFFPEPDDVE S
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human MSL1 (NP_001012241).
- Isotype
- IgG
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- MSL1 (Male-Specific Lethal 1 Homolog (MSL1))
- Alternative Name
- MSL1
- Background
- Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub. This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me and 'Lys-79' (H3K79me and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.,MSL-1,hMSL1,MSL1,Epigenetics & Nuclear Signaling,Histones,MSL1
- Gene ID
- 339287
- UniProt
- Q68DK7
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