MOV10 antibody

Catalog No. ABIN7268678

The Rabbit Monoclonal anti-MOV10 antibody has been validated for WB. It is suitable to detect MOV10 in samples from Human.

Quick Overview for MOV10 antibody (ABIN7268678)

Target: MOV10 (Moloney Leukemia Virus 10 (MOV10))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MOV10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MOV10 Antibody

Purpose: MOV10 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human MOV10

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MOV10

Target: MOV10 (Moloney Leukemia Virus 10 (MOV10))

Alternative Name: MOV10

Background: 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC. Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1 in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity. May function as a messenger ribonucleoprotein (mRNP clearance factor. Exhibits antiviral activity against dengue virus (DENV.,fSAP113, gb110,Epigenetics & Nuclear Signaling,RNA Binding,MOV10

Molecular Weight: 114kDa

Gene ID: 4343

UniProt: Q9HCE1

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome