NCAPD2 antibody

Catalog No. ABIN7268948

The Rabbit Monoclonal anti-NCAPD2 antibody has been validated for WB. It is suitable to detect NCAPD2 in samples from Human.

Quick Overview for NCAPD2 antibody (ABIN7268948)

Target: NCAPD2 (Non-SMC Condensin I Complex, Subunit D2 (NCAPD2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NCAPD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NCAPD2 Antibody

Purpose: CNAP1 Rabbit mAb

Cross-Reactivity: Human, Mouse

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human CNAP1.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NCAPD2

Target: NCAPD2 (Non-SMC Condensin I Complex, Subunit D2 (NCAPD2))

Alternative Name: CNAP1

Background: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.,NCAPD2, CAP-D2, CNAP1, hCAP-D2, condensin complex subunit 1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,CNAP1

Molecular Weight: 150kDa

Gene ID: 9918

UniProt: Q15021