NCAPD2 antibody (C-Term)

Catalog No. ABIN2782540

This Rabbit Polyclonal antibody specifically detects NCAPD2 in WB. It exhibits reactivity toward Human, Dog, Horse, Pig and Rabbit.

Quick Overview for NCAPD2 antibody (C-Term) (ABIN2782540)

Target: NCAPD2 (Non-SMC Condensin I Complex, Subunit D2 (NCAPD2))

Reactivity: Human, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCAPD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NCAPD2 Antibody

Binding Specificity: C-Term

Purpose: NCAPD2 Antibody - C-terminal region

Sequence: KAIIDEFEQK LRACHTRGLD GIKELEIGQA GSQRAPSAKK PSTGSRYQPL

Predicted Reactivity: Dog: 79%, Horse: 93%, Human: 100%, Pig: 92%, Rabbit: 92%

Characteristics: This is a rabbit polyclonal antibody against NCAPD2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NCAPD2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8106612

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NCAPD2

Target: NCAPD2 (Non-SMC Condensin I Complex, Subunit D2 (NCAPD2))

Alternative Name: NCAPD2

Background:

Targeted Subunit: 1

Background Information: NCAPD2 is the regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. NCAPD2 may target the condensin complex to DNA via its C-terminal domain.

Gene Name: Non-SMC condensin I complex, subunit D2

Alternative Symbols: CNAP1, CAP-D2, MCPH21, hCAP-D2

Protein Name: Condensin complex subunit 1

Molecular Weight: 157kDa

Gene ID: 9918

NCBI Accession: NP_055680

UniProt: Q15021