OTUD7B antibody (AA 530-700)

Catalog No. ABIN7269125

The Rabbit Polyclonal anti-OTUD7B antibody has been validated for WB, IHC and IF. It is suitable to detect OTUD7B in samples from Human.

Quick Overview for OTUD7B antibody (AA 530-700) (ABIN7269125)

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD7B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-OTUD7B Antibody

Binding Specificity: AA 530-700

Purpose: OTUD7B Rabbit pAb

Sequence: SKPGGVGTGL GGSSGTETLE KKKKNSLKSW KGGKEEAAGD GPVSEKPPAE SVGNGGSKYS QEVMQSLSIL RTAMQGEGKF IFVGTLKMGH RHQYQEEMIQ RYLSDAEERF LAEQKQKEAE RKIMNGGIGG GPPPAKKPEP DAREEQPTGP PAESRAMAFS TGYPGDFTIP R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 530-700 of human OTUD7B (NP_064590.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Alternative Name: OTUD7B

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro, however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin.,OTUD7B,CEZANNE,ZA20D1,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,OTUD7B

Molecular Weight: 88kDa/92kDa

Gene ID: 56957

UniProt: Q6GQQ9