OTUD7B antibody (AA 235-347) (HRP)

Catalog No. ABIN7162341

Product Details anti-OTUD7B Antibody (HRP)

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Binding Specificity: AA 235-347

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD7B antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human OTU domain-containing protein 7B protein (235-347AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Alternative Name: OTUD7B (OTUD7B Products)

Synonyms: OTUD7B antibody, ZA20D1 antibody, za20d1 antibody, zgc:152772 antibody, cezanne antibody, CEZANNE antibody, 2900060B22Rik antibody, 4930463P07Rik antibody, AI462125 antibody, Trabid2 antibody, Za20d1 antibody, RGD1308111 antibody, OTU deubiquitinase 7B antibody, OTU domain containing 7B antibody, OTUD7B antibody, otud7b antibody, Otud7b antibody

Background:

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates \'Lys-48\'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward \'Lys-11\', \'Lys-48\' and \'Lys-63\'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with \'Lys-11\'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

Aliases: Cellular zinc finger anti NF kappa B protein antibody, Cellular zinc finger anti-NF-kappa-B protein antibody, CEZANNE antibody, HGNC:16683 antibody, OTU domain containing protein 7B antibody, OTU domain-containing protein 7B antibody, OTU7B_HUMAN antibody, OTUD7B antibody, ZA20D1 antibody, Zinc finger A20 domain containing protein 1 antibody, Zinc finger A20 domain-containing protein 1 antibody, Zinc finger protein Cezanne antibody

UniProt: Q6GQQ9