PYM antibody

Catalog No. ABIN7269181

This Rabbit Polyclonal antibody specifically detects PYM in WB and IF. It exhibits reactivity toward Human.

Quick Overview for PYM antibody (ABIN7269181)

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PYM Antibody

Purpose: PYM1 Rabbit pAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human PYM1.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PYM

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Alternative Name: PYM1

Background: Key regulator of the exon junction complex (EJC, a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.,PYM, WIBG,Epigenetics & Nuclear Signaling,PYM1

Gene ID: 84305

UniProt: Q9BRP8