PCBP1 antibody

Catalog No. ABIN7269448

This Rabbit Monoclonal antibody specifically detects PCBP1 in WB. It exhibits reactivity toward Human.

Quick Overview for PCBP1 antibody (ABIN7269448)

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PCBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PCBP1 Antibody

Purpose: hnRNP E1/PCBP1 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human hnRNP E1/hnRNP E1/PCBP1.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PCBP1

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Alternative Name: PCBP1

Background: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.,PCBP1; HEL-S-85; HNRPE1; HNRPX; hnRNP-E1; hnRNP-X; poly(rC)-binding protein 1,Epigenetics & Nuclear Signaling,RNA Binding,,PCBP1

Molecular Weight: 40kDa

Gene ID: 5093

UniProt: Q15365