Protein Virilizer Homolog (VIRMA) (AA 1400-1700) antibody

Catalog No. ABIN7269712

Product Details

Target: Protein Virilizer Homolog (VIRMA)

Binding Specificity: AA 1400-1700

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Purpose: KIAA1429 Rabbit pAb

Sequence: FMRQILNSDT IGCCGDDNGL MEVEGAHTSR TMSINAAELK QLLQSKEESP ENLFLELEKL VLEHSKDDDN LDSLLDSVVG LKQMLESSGD PLPLSDQDVE PVLSAPESLQ NLFNNRTAYV LADVMDDQLK SMWFTPFQAE EIDTDLDLVK VDLIELSEKC CSDFDLHSEL ERSFLSEPSS PGRTKTTKGF KLGKHKHETF ITSSGKSEYI EPAKRAHVVP PPRGRGRGGF GQGIRPHDIF RQRKQNTSRP PSMHVDDFVA AESKEVVPQD GIPPPKRPLK VSQKISSRGG FSGNRGGRGA F

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human KIAA1429 (NP_056311.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: Protein Virilizer Homolog (VIRMA)

Alternative Name: VIRMA

Background: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA.,KIAA1429,MSTP054,fSAP121,VIRMA,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,VIRMA

Molecular Weight: 128kDa/154kDa/201kDa/202kDa

Gene ID: 25962

UniProt: Q69YN4