Reticulon 3 antibody (C-Term)

Catalog No. ABIN7269929

The Rabbit Polyclonal anti-Reticulon 3 antibody has been validated for WB. It is suitable to detect Reticulon 3 in samples from Human.

Quick Overview for Reticulon 3 antibody (C-Term) (ABIN7269929)

Target: Reticulon 3 (RTN3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Reticulon 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Reticulon 3 Antibody

Binding Specificity: C-Term

Purpose: RTN3 Rabbit pAb

Sequence: YKSVIQAVQK SEEGHPFKAY LDVDITLSSE AFHNYMNAAM VHINRALKLI IRLFLVEDLV DSLKLAVFMW LMTYVGAVFN GITLLILAEL LIFSVPIVYE KYKTQIDHYV GIARDQTKSI VEKIQAKLPG IAKKKAE

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Reticulon 3

Target: Reticulon 3 (RTN3)

Alternative Name: RTN3

Background: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.,RTN3,ASYIP,HAP,NSPL2,NSPLII,RTN3-A1,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,RTN3

Molecular Weight: 23kDa/25kDa/26kDa/27kDa/100kDa/110kDa/112kDa

Gene ID: 10313

UniProt: O95197