RHBDD1 antibody (AA 206-315)

Catalog No. ABIN7269978

This anti-RHBDD1 antibody is a Rabbit Polyclonal antibody detecting RHBDD1 in WB and IF. Suitable for Human.

Quick Overview for RHBDD1 antibody (AA 206-315) (ABIN7269978)

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHBDD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RHBDD1 Antibody

Binding Specificity: AA 206-315

Purpose: RHBDD1 Rabbit pAb

Sequence: TQGPLKKIME ACAGGFSSSV GYPGRQYYFN SSGSSGYQDY YPHGRPDHYE EAPRNYDTYT AGLSEEEQLE RALQASLWDR GNTRNSPPPY GFHLSPEEMR RQRLHRFDSQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 206-315 of human RHBDD1 (NP_115652.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RHBDD1

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Alternative Name: RHBDD1

Background: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion, inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis, modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis, inhibits apoptotic activity in spermatogonia.,RHBDD1,RRP4,Cell Biology & Developmental Biology,Apoptosis,RHBDD1

Molecular Weight: 12kDa/35kDa

Gene ID: 84236

UniProt: Q8TEB9