SESN1 antibody

Catalog No. ABIN7270259

The Rabbit Monoclonal anti-SESN1 antibody has been validated for WB and IHC. It is suitable to detect SESN1 in samples from Human.

Quick Overview for SESN1 antibody (ABIN7270259)

Target: SESN1 (Sestrin 1 (SESN1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SESN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SESN1 Antibody

Purpose: sestrin 1 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human sestrin 1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Alternative Name: SESN1

Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],PA26, SEST1,AMPK Signaling Pathway,Cell Biology & Developmental Biology,Endocrine & Metabolism,Endocrine and metabolic diseases,Endocrine and metabolic diseases_Obesity,SESN1

Molecular Weight: 70kDa

Gene ID: 27244

UniProt: Q9Y6P5