SESN1 antibody (AA 271-320)

Catalog No. ABIN1535359

The Rabbit Polyclonal anti-SESN1 antibody is suitable to detect SESN1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for SESN1 antibody (AA 271-320) (ABIN1535359)

Target: SESN1 (Sestrin 1 (SESN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SESN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SESN1 Antibody

Binding Specificity: AA 271-320

Purpose: PA26 Antibody

Specificity: PA26 Polyclonal Antibody detects endogenous levels of PA26 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Alternative Name: SESN1

Background:

Synonyms: SESN1, PA26, SEST1, Sestrin-1, p53-regulated protein PA26

Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

Gene Name: SESN1

Protein Name: Sestrin-1

Molecular Weight: 56 kDa

Gene ID: 27244

OMIM: 606103

UniProt: Q9Y6P5