SPTA1 antibody

Catalog No. ABIN7270517

The Rabbit Monoclonal anti-SPTA1 antibody has been validated for WB. It is suitable to detect SPTA1 in samples from Human.

Quick Overview for SPTA1 antibody (ABIN7270517)

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SPTA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPTA1 Antibody

Purpose: alpha 1 Spectrin Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human alpha 1 Spectrin

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPTA1

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Alternative Name: SPTA1

Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008],EL2, HPP, HS3, SPH3, SPTA,Blood,Blood_Blood Cell Antigens,Cardiovascular,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microfilaments,Signal Transduction,SPTA1

Molecular Weight: 280kDa

Gene ID: 6708

UniProt: P02549

Pathways: Regulation of Actin Filament Polymerization