TAF1 antibody (AA 1630-1893)

Catalog No. ABIN7270713

This anti-TAF1 antibody is a Rabbit Polyclonal antibody detecting TAF1 in WB and IHC. Suitable for Human.

Quick Overview for TAF1 antibody (AA 1630-1893) (ABIN7270713)

Target: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TAF1 Antibody

Binding Specificity: AA 1630-1893

Purpose: TAF1 Rabbit pAb

Sequence: EHLTQLEKDI CTAKEAALEE AELESLDPMT PGPYTPQPPD LYDTNTSLSM SRDASVFQDE SNMSVLDIPS ATPEKQVTQE GEDGDGDLAD EEEGTVQQPQ ASVLYEDLLM SEGEDDEEDA GSDEEGDNPF SAIQLSESGS DSDVGSGGIR PKQPRMLQEN TRMDMENEES MMSYEGDGGE ASHGLEDSNI SYGSYEEPDP KSNTQDTSFS SIGGYEVSEE EEDEEEEEQR SGPSVLSQVH LSEDEEDSED FHSIAGDSDL DSDE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1893 of human TAF1 (NP_004597.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TAF1

Target: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Alternative Name: TAF1

Background: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N-and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons.,TAF1,BA2R,CCG1,CCGS,DYT3,DYT3/TAF1,KAT4,MRXS33,N-TAF1,NSCL2,OF,P250,TAF(II)250,TAF2A,TAFII-250,TAFII250,XDP,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Acetylation,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,TAF1

Molecular Weight: 174-182kDa, 204-216kDa

Gene ID: 6872

UniProt: P21675