TTC3 antibody (AA 1400-1700)

Catalog No. ABIN7270791

This anti-TTC3 antibody is a Rabbit Polyclonal antibody detecting TTC3 in WB. Suitable for Human.

Quick Overview for TTC3 antibody (AA 1400-1700) (ABIN7270791)

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TTC3 Antibody

Binding Specificity: AA 1400-1700

Purpose: TTC3 Rabbit pAb

Sequence: IASETQILEG SLGISVKSHC STGDAHTVLS ESNRNDEHCG NSNNKCEVIP ESTSAVTNIP HVQMVAIQVS WNIIHQEVNT EPYNPFEERQ GEISRIEKEH QVLQDQLQEV YENYEQIKLK GLEETRDLEE KLKRHLEENK ISKTELDWFL QDLEREIKKW QQEKKEIQER LKSLKKKIKK VSNASEMYTQ KNDGKEKEHE LHLDQSLEIS NTLTNEKMKI EEYIKKGKED YEESHQRAVA AEVSVLENWK ESEVYKLQIM ESQAEAFLKK LGLISRDPAA YPDMESDIRS WELFLSNVTK E

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human TTC3 (NP_003307.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TTC3

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Alternative Name: TTC3

Background: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3 in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation.,TTC3,DCRR1,RNF105,TPRDIII,Signal Transduction,G protein signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Neuroscience,TTC3

Molecular Weight: 194kDa/203kDa/229kDa

Gene ID: 7267

UniProt: P53804