TXK antibody (AA 1-180)

Catalog No. ABIN7271114

The Rabbit Polyclonal anti-TXK antibody has been validated for WB. It is suitable to detect TXK in samples from Human.

Quick Overview for TXK antibody (AA 1-180) (ABIN7271114)

Target: TXK (TXK tyrosine Kinase (TXK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TXK Antibody

Binding Specificity: AA 1-180

Purpose: TXK Rabbit pAb

Sequence: MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH

Cross-Reactivity: Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TXK (NP_003319.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TXK

Target: TXK (TXK tyrosine Kinase (TXK))

Alternative Name: TXK

Background: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC activate T-cell receptor (TCR, a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.,TXK,BTKL,PSCTK5,PTK4,RLK,TKL,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Tyrosine kinases,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,TXK

Molecular Weight: 61kDa

Gene ID: 7294

UniProt: P42681

Pathways: Regulation of Leukocyte Mediated Immunity, Hepatitis C