ZIC2 antibody (AA 1-220)

Catalog No. ABIN7271432

The Rabbit Polyclonal anti-ZIC2 antibody has been validated for WB. It is suitable to detect ZIC2 in samples from Human.

Quick Overview for ZIC2 antibody (AA 1-220) (ABIN7271432)

Target: ZIC2

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZIC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZIC2 Antibody

Binding Specificity: AA 1-220

Purpose: ZIC2 Rabbit pAb

Sequence: MLLDAGPQFP AIGVGSFARH HHHSAAAAAA AAAEMQDREL SLAAAQNGFV DSAAAHMGAF KLNPGAHELS PGQSSAFTSQ GPGAYPGSAA AAAAAAALGP HAAHVGSYSG PPFNSTRDFL FRSRGFGDSA PGGGQHGLFG PGAGGLHHAH SDAQGHLLFP GLPEQHGPHG SQNVLNGQMR LGLPGEVFGR SEQYRQVASP RTDPYSAAQL HNQYGPMNMN

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZIC2

Target: ZIC2

Alternative Name: ZIC2

Background: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.,ZIC2,HPE5,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,Neuroscience,ZIC2

Molecular Weight: 55kDa

Gene ID: 7546

UniProt: O95409

Pathways: Tube Formation