ZCCHC3 antibody (AA 215-335)

Catalog No. ABIN7271543

The Rabbit Polyclonal anti-ZCCHC3 antibody is suitable to detect ZCCHC3 in samples from Human. It has been validated for WB and IF.

Quick Overview for ZCCHC3 antibody (AA 215-335) (ABIN7271543)

Target: ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZCCHC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ZCCHC3 Antibody

Binding Specificity: AA 215-335

Purpose: ZCCHC3 Rabbit pAb

Sequence: SFRSAEKLAL FLRVYEEKRE QEDCWENFVV LGRSKSSLKT LFILFRNETV DVEDIVTWLK RHCDVLAVPV KVTDRFGIWT GEYKCEIELR QGEGGVRHLP GAFFLGAERG YSWYKGQPKT C

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 215-335 of human ZCCHC3 (NP_149080.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZCCHC3

Target: ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))

Alternative Name: ZCCHC3

Background: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus. Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation. Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA, enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5.,ZCCHC3,C20orf99,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,ZCCHC3

Molecular Weight: 43kDa

Gene ID: 85364

UniProt: Q9NUD5