ZIKV E
Reactivity: Virus
ELISA
Host: Mouse
Monoclonal
ID5
unconjugated
Application Notes
WB 1:1000-1:5000 ELISA 1:1000-1:2000
Restrictions
For Research Use only
Concentration
1 mg/mL
Buffer
0.2 μm filtered solution in PBS
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target
ZIKV E
(Zika Virus Envelope (ZIKV E))
Alternative Name
ZIKV Envelope Protein
Background
E,Envelope Protein,Envelope of Zika virus is resposible for receptor binding and membrane. Analysis of the envelope protein of Zika, from Brazilian Zika SPH215 (KU321639), indicates predicted B and T cell epitopes in peptides that are consistent to those reported for dengue, YFYF and Japanese encephalitis. The envelope Domain II B cell epitope, to which much dengue non-neutralizing cross reaction is attributed, is also conserved also in Zika virus, consistent with prior field observations of cross reactivity with dengue and YF. Domain III of the Zika envelope protein, likely the main specific neutralizing domain, is distinct from recent Brazilian dengue isolates and a recent Peruvian YF isolate (GQ379163), 76 % of possible major histocompatibility complex class (MHC) I and MHC II binding peptides and potential B cell linear epitopes are unique to Zika virus.