APC antibody

Catalog No. ABIN7384414

This anti-APC antibody is a Rabbit Monoclonal antibody detecting APC in WB. Suitable for Human.

Quick Overview for APC antibody (ABIN7384414)

Target: APC (Adenomatous Polyposis Coli (APC))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This APC antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R06-2E4

Product Details anti-APC Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for APC

Target: APC (Adenomatous Polyposis Coli (APC))

Alternative Name: APC

Background: Adenomatous Polyposis Coli,Adenomatous polyposis coli protein,Apc,APC,CC1,Deleted in polyposis 2.5,DP2,DP2.5,DP3,FAP,FPC,GS,Protein APC,This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Molecular Weight:

Observed_MW: 160kDa

Calculated_MW: 312kDa

Gene ID: 324

UniProt: P25054

Pathways: WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization