BCR antibody

Catalog No. ABIN7384420

The Rabbit Monoclonal anti-BCR antibody (Clone R02-6I0) (ABIN7384420) specifically detects BCR in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for BCR antibody (ABIN7384420)

Target: BCR (Breakpoint Cluster Region (BCR))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BCR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R02-6I0

Product Details anti-BCR Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000 IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Alternative Name: Bcr

Background: ALL,bcr,BCR1,Breakpoint cluster region,CML,D22S11,D22S662,PHL,Renal carcinoma antigen NY-REN-26,A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 160kDa

Calculated_MW: 143kDa

Gene ID: 613

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling