C-AMP Protein Kinase (Catalytic Subunit) antibody

Catalog No. ABIN7384424

This Rabbit Monoclonal antibody specifically detects C-AMP Protein Kinase in WB, IP, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for C-AMP Protein Kinase (Catalytic Subunit) antibody (ABIN7384424)

Target: C-AMP Protein Kinase

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R07-8H3

Product Details

Binding Specificity: Catalytic Subunit

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000 IHC 1:50-1:100 IF 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: C-AMP Protein Kinase

Alternative Name: cAMP Protein Kinase

Background: CAMP dependent protein kinase alpha catalytic subunit,cAMP dependent protein kinase beta catalytic subunit,cAMP dependent protein kinase catalytic beta subunit isoform 4ab,cAMP dependent protein kinase catalytic subunit alpha,cAMP dependent protein kinase catalytic subunit alpha,isoform 1,cAMP dependent protein kinase catalytic subunit beta,cAMP-dependent protein kinase catalytic subunit alpha,KAPCA,PKA C alpha,PKA C beta,PKA C-alpha,PKACA,PKACB,PPNAD4,PRKACA,PRKACAA,PRKACB,Protein kinase A catalytic subunit alpha,Protein kinase A catalytic subunit,Protein kinase A catalytic subunit beta,Protein kinase cAMP dependent catalytic alpha,Protein kinase cAMP dependent catalytic beta,This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Molecular Weight:

Observed_MW: 41kDa

Calculated_MW: 41kDa

Gene ID: 5566

UniProt: P17612