XBP1 antibody

Catalog No. ABIN7384507

This anti-XBP1 antibody is a Rabbit Monoclonal antibody detecting XBP1 in WB. Suitable for Human and Mouse.

Quick Overview for XBP1 antibody (ABIN7384507)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This XBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R04-3E2

Product Details anti-XBP1 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Alternative Name: XBP1

Background: Tax responsive element binding protein 5,Tax-responsive element-binding protein 5,TREB5,X box binding protein 1,X box binding protein 2,X-box-binding protein 1,XBP 1,XBP-1,XBP1,XBP1,XBP2,This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

Molecular Weight:

Observed_MW: 29kDa

Calculated_MW: 29kDa

Gene ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response