DROSHA antibody (AA 1050-1100)

Catalog No. ABIN7448535

The Rabbit Polyclonal anti-DROSHA antibody (ABIN7448535) specifically detects DROSHA in IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for DROSHA antibody (AA 1050-1100) (ABIN7448535)

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DROSHA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DROSHA Antibody

Binding Specificity: AA 1050-1100

Purpose: Rabbit anti-Drosha IHC Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1050 and 1100

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DROSHA

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Alternative Name: Drosha

Background: Background: Drosha is one of three human RNase III enzymes (Drosha, Dicer, and Argonaute) that play a diverse role in the processing and maturation of RNA. Drosha, along with DGCR8 (DeGeorge Syndrome Chromomsomal Region 8, also known as Pasha in C. elegans and D. melanogaster) is a component of the Microprocessor complex. In this complex, Drosha functions as a double-stranded endoribonuclease critical to the first step in the processing of human microRNAs. During this step, Drosha is responsible for cleaving pri-miRNA to yield hairpin-shaped pre-miRNA for futher processing by the cytoplasmic RNase III enzyme, Dicer.

Gene ID: 29102

NCBI Accession: NP_037367

UniProt: Q9NRR4

Pathways: Regulatory RNA Pathways