BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 175-225) antibody

Catalog No. ABIN7448667

This anti- antibody is a Rabbit Polyclonal antibody detecting in IHC. Suitable for Human.

Quick Overview for BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 175-225) antibody (ABIN7448667)

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 175-225

Purpose: Rabbit anti-MERIT40 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Bovine,Dog,Horse,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,African elephant,Small-eared galago,Chinese hamster,Northern white-cheeked gibbon,Crab-eating macaque,Thirteen-lined ground squirrel,Little brown bat

Purification: Affinity Purified

Immunogen: Between AA 175 and 225

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Alternative Name: MERIT40

Background: Background: MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) Q9NWV8].

Gene ID: 29086

NCBI Accession: NP_054892

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus