Prohibitin antibody (AA 222-272)
Quick Overview for Prohibitin antibody (AA 222-272) (ABIN7448745)
Target
See all Prohibitin (PHB) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 222-272
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Purpose
- Rabbit anti-Prohibitin IHC Antibody, Affinity Purified
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Predicted Reactivity
- Mouse,Rat,Bovine,Dog,Rabbit,Guinea pig_10141,Pig,Panda,Cat,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Naked mole rat,Gray short-tailed opossum,Little brown bat,Chinese hamster,Northern white-cheeked gibbon,Crab-eating macaque,Tasmanian devil,Thirteen-lined ground squirrel,Small-eared galago
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Purification
- Affinity Purified
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Immunogen
- Between AA 222 and 272
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Isotype
- IgG
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Application Notes
- 1:100 - 1:500
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Restrictions
- For Research Use only
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Concentration
- 250 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Expiry Date
- 12 months
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- Prohibitin (PHB)
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Alternative Name
- Prohibitin
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Background
- Background: Prohibitin (PHB) has been identified as a tumor suppressor protein that can repress E2F-mediated transcription and arrest cell cycle progression. It has recently been shown to associate with members of the minichromosome maintenance complex such as MCM2, MCM5, and MCM7 and therefore is thought to impart its growth inhibitory effects via association with the replication machinery. Prohibitin is also implicated in regulating mitochondrial respiration and playing a role in aging.
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Gene ID
- 5245
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NCBI Accession
- NP_002625
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UniProt
- P35232
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Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
Target
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