Aurora Kinase B antibody (C-Term)

Catalog No. ABIN7448917

This Rabbit Polyclonal antibody specifically detects Aurora Kinase B in IHC and IF/ICC. It exhibits reactivity toward Human.

Quick Overview for Aurora Kinase B antibody (C-Term) (ABIN7448917)

Target: Aurora Kinase B (AURKB)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase B antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)

Product Details anti-Aurora Kinase B Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-Aurora B IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque

Purification: Affinity Purified

Immunogen: Between AA 300 and C-term

Isotype: IgG

Application Details

Application Notes:

ICC-IF: 1:100 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: Aurora B

Background: Background: Aurora B is the central enzymatic unit of the chromosomal passenger complex (CPC). In the CPC, Aurora B is associated with the passenger proteins inner centromeric protein (INCENP), survivin, and borealin. Aurora B is a serine-threonine protein kinase essential for chromosome segregation and cytokinesis. Specific roles for Aurora B have been demonstrated in cohesin dissociation from centromeres as well as condensin I binding to chromatin.F112. Substrates of Aurora B kinase activity include desmin, septin 1, INCENP, RAC GTPase activating protein 1, and centromeric protein A.

Gene ID: 9212

NCBI Accession: NP_004208

UniProt: Q96GD4

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades