PDE12 antibody (AA 559-609)

Catalog No. ABIN7449244

This Rabbit Polyclonal antibody specifically detects PDE12 in WB. It exhibits reactivity toward Human.

Quick Overview for PDE12 antibody (AA 559-609) (ABIN7449244)

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE12 Antibody

Binding Specificity: AA 559-609

Purpose: Rabbit anti-PDE12 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Bovine

Purification: Affinity Purified

Immunogen: Between AA 559 and 609

Isotype: IgG

Application Details

Application Notes: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PDE12

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Alternative Name: PDE12

Background: Background: PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system [taken from the Universal Protein Resource (UniProt) Q6L8Q7].

Gene ID: 201626

UniProt: Q6L8Q7