p40 (p63 Delta) (AA 1-50) antibody

Catalog No. ABIN7449374

The Mouse Monoclonal anti- antibody has been validated for WB and IHC. It is suitable to detect in samples from Human.

Quick Overview for p40 (p63 Delta) (AA 1-50) antibody (ABIN7449374)

Target: p40 (p63 Delta)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: BC28

Product Details

Binding Specificity: AA 1-50

Purpose: Mouse anti-p40 Monoclonal Antibody [BC28]

Immunogen: between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

WB: 17:40:00

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details

Target: p40 (p63 Delta)

Alternative Name: p40

Background: Background: Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].

Gene ID: 8626

NCBI Accession: NP_003713

UniProt: Q9H3D4