Desmoplakin antibody (AA 1600-1650)

Catalog No. ABIN7450166

The Rabbit Polyclonal anti-Desmoplakin antibody has been validated for WB and IP. It is suitable to detect Desmoplakin in samples from Human.

Quick Overview for Desmoplakin antibody (AA 1600-1650) (ABIN7450166)

Target: Desmoplakin (DSP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoplakin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Desmoplakin Antibody

Binding Specificity: AA 1600-1650

Purpose: Rabbit anti-Desmoplakin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1600 and 1650

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Desmoplakin

Target: Desmoplakin (DSP)

Alternative Name: Desmoplakin

Background: Background: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in DSP, the gene encoding desmoplakin, are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus [taken from NCBI Entrez Gene (Gene ID: 1832)].

Gene ID: 1832

NCBI Accession: NP_004406

UniProt: P15924

Pathways: Cell-Cell Junction Organization