Importin 11 antibody (AA 925-975)

Catalog No. ABIN7450360

This Rabbit Polyclonal antibody specifically detects Importin 11 in WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for Importin 11 antibody (AA 925-975) (ABIN7450360)

Target: Importin 11 (IPO11)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 11 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Importin 11 Antibody

Binding Specificity: AA 925-975

Purpose: Rabbit anti-Importin 11/IPO11 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 925 and 975

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Importin 11

Target: Importin 11 (IPO11)

Alternative Name: Importin 11/IPO11

Background: Background: Importin 11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Importin 11/IPO11 mediates the nuclear import of UBE2E3, and of RPL12 (By similarity) [taken from the Universal Protein Resource (UniProt) Q9UI26].

Gene ID: 51194

UniProt: Q9UI26

Pathways: Protein targeting to Nucleus