ISR-beta antibody (AA 1332-1382)

Catalog No. ABIN7450366

This Rabbit Polyclonal antibody specifically detects ISR-beta in WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for ISR-beta antibody (AA 1332-1382) (ABIN7450366)

Target: ISR-beta (Insulin Receptor beta (ISR-beta))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISR-beta antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-ISR-beta Antibody

Binding Specificity: AA 1332-1382

Purpose: Rabbit anti-Insulin Receptor Beta Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1332 and 1382

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ISR-beta

Target: ISR-beta (Insulin Receptor beta (ISR-beta))

Alternative Name: Insulin Receptor Beta

Background: Background: The insulin receptor is a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates to stimulate uptake of glucose. The insulin receptor is synthesized as a single polypeptide that is cleaved to generate an alpha and beta subunit. The subunit structure of the insulin receptor consists of a tetramer of two alpha and two beta chains linked by disulfide bonds.

Gene ID: 3643

NCBI Accession: NP_000199

UniProt: P06213