SPG20 antibody (AA 350-400)

Catalog No. ABIN7450761

The Rabbit Polyclonal anti-SPG20 antibody (ABIN7450761) specifically detects SPG20 in WB and IP. The antibody is reactive with Human samples.

Quick Overview for SPG20 antibody (AA 350-400) (ABIN7450761)

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG20 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-SPG20 Antibody

Binding Specificity: AA 350-400

Purpose: Rabbit anti-SPG20 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 350 and 400

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SPG20

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Alternative Name: SPG20

Background: Background: Spastic paraplegia 20 protein (SPG20) is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Mutations associated with the SPG20 gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome) [taken from NCBI Entrez Gene (Gene ID: 23111)].

Gene ID: 23111

UniProt: Q8N0X7

Pathways: Regulation of Cell Size, SARS-CoV-2 Protein Interactome