USP11 antibody (AA 870-920)

Catalog No. ABIN7450882

This Rabbit Polyclonal antibody specifically detects USP11 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for USP11 antibody (AA 870-920) (ABIN7450882)

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP11 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-USP11 Antibody

Binding Specificity: AA 870-920

Purpose: Rabbit anti-USP11 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 870 and 920

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for USP11

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Alternative Name: USP11

Background: Background: Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 11 (USP11) is a member of this family. USP11 has been found to associate with several proteins and may have functions independent of its deubiquitinating activity. USP11 deubiquitinates and associates with the RanGTP-binding protein, RanBPM. It has also been found to associate with BRCA2 and participate in the BRCA2 DNA damage related pathway, however, it does not appear to be involved in BRCA2 deubiquitination. USP11 also appears to play a role in the regulation of the IKKalpha and p53 signaling pathway by a mechanism independent of it deubiquitination activity.

Gene ID: 8237

UniProt: P51784