FAM120A antibody (AA 1068-1118)

Catalog No. ABIN7451012

The Rabbit Polyclonal anti-FAM120A antibody has been validated for WB and IP. It is suitable to detect FAM120A in samples from Human and Mouse. There is 1 publication available.

Quick Overview for FAM120A antibody (AA 1068-1118) (ABIN7451012)

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM120A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-FAM120A Antibody

Binding Specificity: AA 1068-1118

Purpose: Rabbit anti-OSSA Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1068 and 1118

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

References for anti-FAM120A antibody (ABIN7451012)

Lobo, Nowak, Fernandez, Correa Muler, Westholm, Huang, Fabrik, Huynh, Shcherbinina, Poyraz, Härtlova, Benhalevy, Angeletti, Sarshad: "Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference." in: Nucleic acids research, Vol. 52, Issue 16, pp. 9917-9935, (2024) (PubMed).

Target Details for FAM120A

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Alternative Name: OSSA

Background: Background: Oxidative stress-associated Src activator (OSSA) may participate in mRNA transport in the cytoplasm (by similarity). OSSA is a critical component of the oxidative stress-induced survival signaling. It activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. It binds RNA and promotes the secretion of IGF-II. OSSA may play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses [taken from the Universal Protein Resource (UniProt) Q9NZB2].

Gene ID: 23196

NCBI Accession: NP_055427

UniProt: Q9NZB2