Mahogunin RING Finger Protein 1 antibody (AA 400-450)

Catalog No. ABIN7451872

This Rabbit Polyclonal antibody specifically detects Mahogunin RING Finger Protein 1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Mahogunin RING Finger Protein 1 antibody (AA 400-450) (ABIN7451872)

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mahogunin RING Finger Protein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Mahogunin RING Finger Protein 1 Antibody

Binding Specificity: AA 400-450

Purpose: Rabbit anti-MGRN1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 400 and 450

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Mahogunin RING Finger Protein 1

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Alternative Name: MGRN1

Background: Background: MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) O60291].

Gene ID: 23295

NCBI Accession: NP_001135761

UniProt: O60291

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling