SUZ12 antibody (AA 689-739)

Catalog No. ABIN7452078

This anti-SUZ12 antibody is a Rabbit Polyclonal antibody detecting SUZ12 in WB and IP. Suitable for Human and Mouse.

Quick Overview for SUZ12 antibody (AA 689-739) (ABIN7452078)

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUZ12 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-SUZ12 Antibody

Binding Specificity: AA 689-739

Purpose: Rabbit anti-SUZ12 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 689 and 739

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SUZ12

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Alternative Name: SUZ12

Background: Background: SUZ12 (suppressor of zeste 12) is the human homolog of the drosophila SUZ12 gene. SUZ12 is a Polycomb group (PcG) protein and a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. A chromosomal aberration, t(7,17)(p15,q21), involving SUZ12 and JAZF1 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer [taken from the Universal Protein Resource (UniProt) Q15022].

Gene ID: 23512

NCBI Accession: NP_056170

UniProt: Q15022