SOS1 antibody (AA 1025-1075)

Catalog No. ABIN7452439

This Rabbit Polyclonal antibody specifically detects SOS1 in IP. It exhibits reactivity toward Human.

Quick Overview for SOS1 antibody (AA 1025-1075) (ABIN7452439)

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOS1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-SOS1 Antibody

Binding Specificity: AA 1025-1075

Purpose: Rabbit anti-SOS1 Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: between AA 1025 and 1075

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-SOS1 antibody ABIN7452055.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SOS1

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Alternative Name: SOS1

Background: Background: SOS1 (son of sevenless homolog 1) is a human paralog of the drosophila SOS gene. Drosophila SOS was originally identified as a gene that functioned downstream of the sevenless gene in the Ras/MAP kinase signaling pathway. SOS and its paralogs, SOS1 and SOS2, function as guanine nucleotide exchange factors that act on Ras-GTPases to cause release of GDP in exchange for GTP. Mutations in SOS1 are the cause of Noonan syndrome type 4 and gingival fibromatosis.

Gene ID: 6654

NCBI Accession: NP_005624

UniProt: Q07889

Pathways: RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling