Caveolin-1 antibody (AA 1-50)

Catalog No. ABIN7452652

This Rabbit Polyclonal antibody specifically detects Caveolin-1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Caveolin-1 antibody (AA 1-50) (ABIN7452652)

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caveolin-1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Caveolin-1 Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-CAV1 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Sheep,Bovine,Horse,Rabbit,Pig,Cat,Orangutan,Gorilla,Chimpanzee

Purification: Affinity Purified

Immunogen: between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IP: 20-40 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Caveolin-1

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Alternative Name: CAV1

Background: Background: CAV1 acts as a scaffolding protein within caveolar membranes and forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. CAV1 also mediates the recruitment of CAVIN proteins to the caveolae and interacts directly with G-protein alpha subunits and can functionally regulate their activity. CAV1 is also thought to be involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, as its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner  [taken from the Universal Protein Resource (UniProt) Q03135].

Gene ID: 857

NCBI Accession: NP_001744

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals