RASAL1 antibody (AA 754-804)

Catalog No. ABIN7452836

The Rabbit Polyclonal anti-RASAL1 antibody has been validated for WB and IP. It is suitable to detect RASAL1 in samples from Human.

Quick Overview for RASAL1 antibody (AA 754-804) (ABIN7452836)

Target: RASAL1 (RAS Protein Activator Like 1 (GAP1 Like) (RASAL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASAL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RASAL1 Antibody

Binding Specificity: AA 754-804

Purpose: Rabbit anti-RASAL1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 754 and 804

Isotype: IgG

Application Details

Application Notes:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RASAL1

Target: RASAL1 (RAS Protein Activator Like 1 (GAP1 Like) (RASAL1))

Alternative Name: RASAL1

Background: Background: RASAL1 is a member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, RASAL1 enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, RASAL1 is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010] [taken from NCBI Entrez Gene (Gene ID: 8437)].

Gene ID: 8437

UniProt: O95294