TBC1D23 antibody (AA 525-575)

Catalog No. ABIN7452842

The Rabbit Polyclonal anti-TBC1D23 antibody has been validated for WB and IP. It is suitable to detect TBC1D23 in samples from Human.

Quick Overview for TBC1D23 antibody (AA 525-575) (ABIN7452842)

Target: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D23 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-TBC1D23 Antibody

Binding Specificity: AA 525-575

Purpose: Rabbit anti-TBC1D23 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Zebrafish,X. laevis,Chicken,Orangutan

Purification: Affinity Purified

Immunogen: between AA 525 and 575

Isotype: IgG

Application Details

Application Notes:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TBC1D23

Target: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Alternative Name: TBC1D23

Background: Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].

Gene ID: 55773

UniProt: Q9NUY8