ZNF207 antibody (AA 428-478)

Catalog No. ABIN7452845

The Rabbit Polyclonal anti-ZNF207 antibody is suitable to detect ZNF207 in samples from Human and Mouse. It has been validated for WB and IP.

Quick Overview for ZNF207 antibody (AA 428-478) (ABIN7452845)

Target: ZNF207 (Zinc Finger Protein 207 (ZNF207))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF207 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-ZNF207 Antibody

Binding Specificity: AA 428-478

Purpose: Rabbit anti-ZNF207 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: between AA 428 and 478

Isotype: IgG

Application Details

Application Notes:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ZNF207

Target: ZNF207 (Zinc Finger Protein 207 (ZNF207))

Alternative Name: ZNF207

Background: Background: ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) O43670].

Gene ID: 7756

UniProt: O43670