ACLY antibody (AA 1051-1101)

Catalog No. ABIN7452922

This Rabbit Polyclonal antibody specifically detects ACLY in WB. It exhibits reactivity toward Human.

Quick Overview for ACLY antibody (AA 1051-1101) (ABIN7452922)

Target: ACLY (ATP Citrate Lyase (ACLY))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACLY antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACLY Antibody

Binding Specificity: AA 1051-1101

Purpose: Rabbit anti-ACL Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Sheep,Bovine

Purification: Affinity Purified

Immunogen: Between AA 1051 and 1101

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ACLY

Target: ACLY (ATP Citrate Lyase (ACLY))

Alternative Name: ACL

Background: Background: ATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. ACL is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ACL may be involved in the biosynthesis of acetylcholine [taken from NCBI Entrez Gene (Gene ID: 47)].

Gene ID: 47

NCBI Accession: NP_001087

UniProt: P53396

Pathways: Warburg Effect