NOC2L antibody (AA 699-749)
Quick Overview for NOC2L antibody (AA 699-749) (ABIN7453539)
Target
See all NOC2L AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 699-749
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Purpose
- Rabbit anti-NIR Antibody, Affinity Purified
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Purification
- Affinity Purified
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Immunogen
- Between AA 699 and 749
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Isotype
- IgG
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anti-Nucleolar Complex Associated 2 Homolog (NOC2L) antibody
NOC2L Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Nucleolar Complex Associated 2 Homolog (NOC2L) (C-Term) antibodyNOC2L Reactivity: Human, Mouse, Rat WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
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Application Notes
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: Not recommended
WB: 1:2,000 - 1:10,000
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Restrictions
- For Research Use only
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Concentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Expiry Date
- 12 months
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- NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))
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Alternative Name
- NIR
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Background
- Background: Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity, it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) Q9Y3T9].
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Gene ID
- 26155
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NCBI Accession
- NP_056473
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UniProt
- Q9Y3T9
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Pathways
- Negative Regulation of intrinsic apoptotic Signaling
Target
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