NOC2L antibody (AA 699-749)

Catalog No. ABIN7453539

The Rabbit Polyclonal anti-NOC2L antibody (ABIN7453539) specifically detects NOC2L in WB and IHC (fp). The antibody is reactive with Human samples.

Quick Overview for NOC2L antibody (AA 699-749) (ABIN7453539)

Target: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOC2L antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-NOC2L Antibody

Binding Specificity: AA 699-749

Purpose: Rabbit anti-NIR Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 699 and 749

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for NOC2L

Target: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Alternative Name: NIR

Background: Background: Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity, it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) Q9Y3T9].

Gene ID: 26155

NCBI Accession: NP_056473

UniProt: Q9Y3T9

Pathways: Negative Regulation of intrinsic apoptotic Signaling