FLII antibody (AA 425-475)

Catalog No. ABIN7453708

This Rabbit Polyclonal antibody specifically detects FLII in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for FLII antibody (AA 425-475) (ABIN7453708)

Target: FLII (Flightless I Homolog (FLII))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLII antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-FLII Antibody

Binding Specificity: AA 425-475

Purpose: Rabbit anti-Flightless-1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 425 and 475

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FLII

Target: FLII (Flightless I Homolog (FLII))

Alternative Name: Flightless-1

Background: Background: Flightless-1 is the human homolog of the drosophila flightless (fli1), a gene required for proper development of flight muscles and essential to embryonic development. It is a member of the gelsolin family of actin-binding proteins, and is highly conserved among vertebrates and invertebrates. The actin-remodeling activity of flightless-1 may have multiple roles in the cell. Studies in transgenic mice indicate a role in wound healing that may involve the regulation of cell migration and proliferation. Flightless-1 has also been found to be associated with complexes involved in transcriptional regulation. It associates with CARM1, a protein arginine methyltransferase, and may function as a nuclear receptor coactivator via this interaction. It has also been shown to associate with the BAF53a subunit of the SWI/SNF-like chromatin remodeling complexes.

Gene ID: 2314

NCBI Accession: NP_002009

UniProt: Q13045