CD276 antibody (AA 484-534)

Catalog No. ABIN7453930

The Rabbit Polyclonal anti-CD276 antibody has been validated for WB, IP and IHC (fp). It is suitable to detect CD276 in samples from Human.

Quick Overview for CD276 antibody (AA 484-534) (ABIN7453930)

Target: CD276

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-CD276 Antibody

Binding Specificity: AA 484-534

Purpose: Rabbit anti-B7-H3/CD276 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat

Purification: Affinity Purified

Immunogen: Between AA 484 and 534

Isotype: IgG

Application Details

Application Notes:

IHC: 1:2,000 - 1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-B7-H3/CD276 antibody ABIN7453044.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CD276

Target: CD276

Alternative Name: B7-H3/CD276

Background: Background: CD276 may participate in the regulation of T-cell-mediated immune response. CD276 may play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. It may also be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces and could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy [taken from the Universal Protein Resource (UniProt) Q5ZPR3].

Gene ID: 80381

NCBI Accession: NP_001019907

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints