Arrestin 3 antibody (AA 310-360)

Catalog No. ABIN7454497

The Rabbit Polyclonal anti-Arrestin 3 antibody has been validated for IP and IHC (fp). It is suitable to detect Arrestin 3 in samples from Human.

Quick Overview for Arrestin 3 antibody (AA 310-360) (ABIN7454497)

Target: Arrestin 3 (ARRB2) (Arrestin, beta 2 (ARRB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Arrestin 3 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-Arrestin 3 Antibody

Binding Specificity: AA 310-360

Purpose: Rabbit anti-Beta-Arrestin 2 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: Between AA 310 and 360

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Arrestin 3

Target: Arrestin 3 (ARRB2) (Arrestin, beta 2 (ARRB2))

Alternative Name: Beta-Arrestin 2

Background: Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 2, like beta-arrestin 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for beta-arrestin 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. [taken from NCBI Entrez Gene (Gene ID: 409)].

Gene ID: 409

NCBI Accession: NP_004304

UniProt: P32121

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Phototransduction, Thromboxane A2 Receptor Signaling